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Thursday, February 15, 2007
Scientists have discovered a place on the outside part of AIDS virus that might be vulnerable to antibodies blocking the virus from infecting human cells. This could mean that an anti-HIV vaccine is possible in the future.
According to Peter Kwong, researcher at U.S National Institute of Health (NIH), this study is likely to contribute to finding HIV’s “site of vulnerability” which could then be targeted with a vaccine that prevents the initial infection.
The team of researchers have made atomic-level images of HIV and revealed the structure of a protein on the surface of the virus. This protein, called gp120, binds to an infection-fighting antibody and seems to be susceptible to attacks by this antibody called ‘b12’. B12 can broadly neutralize the virus.
Researchers detailed the precise interaction as the virus tries to hook on to and infect cells sent to protect the body. They have captured an image of how the virus of human immunodeficiency attacks the human cells. Dr. Gary Nabel, an NIH vaccine expert and a co-author of the research, describes this first contact between the virus and the cells as a ‘cautious handshake’ which then becomes a ‘hearty bear hug’. The virus grabs and infects the cells that are aimed at protecting the body.
Then the virus mutates quickly to fight the immune system’s attacks as well as to counter the effect of antibodies that block the proteins with help of which HIV binds to a cell to infect it.
Scientists agree that a vaccine against AIDS would be an ideal way to stop the pandemic of this disease, but, with all importance of these findings, much work and studies are still needed. This implies that any vaccine against AIDS is probably still many years away.
The AIDS virus has killed more than 25 million people since it was first detected in 1981. Sub-Saharan Africa is the most severely affected by the epidemic. Approximately 40 million people live with HIV.
About a dozen potential vaccines are currently under development. Two products, one by Merck and one by Sanofi-Aventis, are now in advanced human trials.
Saturday, May 22, 2010
At least six suspects, wanted in connection with a failed car bomb attempt in Times Square, New York City on May 1, have been arrested by authorities in Pakistan. The arrests follow a visit to Pakistan by two high-ranking American security officials—US National Security Adviser Gen James Jones and Leon Panetta, director of the Central Intelligence Agency (CIA), both of whom praised Pakistan for its efforts in tracking down suspects in the bomb attack.
Amongst those arrested are the co-owner of a large company which provides catering to several embassies in Pakistan and a major in the Pakistani Army, though the Army released a statement denying any involvment. Some are believed to have been educated in the United States. A notice on the website of the US embassy in Islamabad reported that the catering company co-owned by one of the suspects had links to terrorism and has since advised US citizens against using the firm.
Those arrested are believed to have had links with Faisal Shahzad, the primary suspect in the bombing, who was arrested on May 3 on board an aircraft at New York’s JFK Airport.
One source told Reuters: “We are investigating whether Ashraf has provided any financial support to Faisal because Ashraf and his father are rich people and they run a very big catering business” though another stated that “[t]hey may be innocent because being friends does not mean you are involved in the activities of your friends”.
The suspects are currently being detained by the Pakistani security services, who are known to have close links with the CIA, to the extent of allowing CIA officials access to prisoners.
How to Increase Your Returns and Add Rental Property Value
by
jamesrkA smart real estate investor always seeks to optimize the performance of his or her rental investment property to achieve maximum profits. In this article we’ll consider several activities that, if done consistently and vigilantly, will help investors to increase returns and add value to the property.
1) Maintain Market Rental Rates
You have to regularly watch the market for rental rate increases. If your competition has increased rents on comparable properties then you should not hesitate to increase your rents as soon as possible. That is, of course, assuming that your rental agreements permit and provided that your property is not under rent-control regulations.
You shouldn’t be timid to raise rents for fear of driving out good tenants without just cause. If there is a large supply of affordable housing available in your area then you are probably wise not to risk a rent increase. Otherwise, bear in mind that inflation affects your cost of doing business and you are just acting prudently to stay current with the optimum market rental rate to maintain profitability.
2) Reduce Vacancy Rates
Of course being able to charge market rent for your units affects your bottom line less when units are vacant. If your vacancy rate is high, then consider ways to attract tenants you are otherwise missing. Incorporating a pet policy, for instance, opens the door for the increasing numbers of tenants who have pets. Also consider some move-in incentives; often good tenants just need a little financial incentive to become tenants in your property.
3) Examine Highest and Best Use
Real estate investors must also understand what the highest and best use is for their property. If your property, for instance, is being used as apartments when there is a shortage and high demand for office space in the neighborhood that would warrant a higher price per square foot than the residential use, perhaps you should consider a change in use.
This would undoubtedly require making capital improvements to the property, but it might be warranted if it means attracting higher income from higher-paying tenants that at the end of the day would increase your long-range returns.
4) Utilize the Property’s Full Rent Potential
A smart investor will seldom give away for free what can be rented, and always rents every bit of the property possible. For example, areas like storage space or garages are regularly rented separately to tenants occupying a unit in the building. So unless they are already made part of the rental agreement, provide them for an additional charge.
The idea is know your property and to be creative; never take any area or space that has the potential to generate rental income for granted, and whenever reasonable possible, charge additional rent for it.
5) Reduce Operating Expenses
It’s common knowledge that profits increase when expenses are reduced. So examine what your annual operating expenses have been running and make sure that they don’t exceed the absolute minimum amount it takes to operate the property. You might discover a plethora of expenses that can be reduced or even omitted that in the long run will save some money and increase potential profits. It doesn’t take much; every $50 a month saved earns you an extra $600 a year.
Okay, now consider how all of this adds value to your investment property.
Real estate investors buy cash flow when they purchase rental property. Therefore it stands to reason that the more income you add and/or operating expenses you reduce, the more value you add to your investment rental property.
For example, cap rate is one of the most popular methods used to determine investment property value. In this case, the net operating income (income less operating expenses) is divided by cap rate to arrive at value. Therefore when you add, say, $5,000 to your property’s annual net operating income and investors in your market are willing to purchase at, say, an 8.0% cap rate, you add $62,500 value to your property.
James Kobzeff is the developer of ProAPOD – superior
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Article Source:
eArticlesOnline.com}
Tuesday, October 14, 2008
The San Diego, California suburb of Chula Vista has responded to the recent housing crisis with an aggressive blight control ordinance that compels lenders to maintain the appearance of vacant homes. As foreclosures increase both locally and throughout the United States, the one year old ordinance has become a model for other cities overwhelmed by the problem of abandoned homes that decay into neighborhood eyesores.
Chula Vista city code enforcement manager Doug Leeper told the San Diego Union Tribune that over 300 jurisdictions have contacted his office during the past year with inquiries about the city’s tough local ordinance. Coral Springs, Florida, and California towns Stockton, Santee, Riverside County, and Murietta have all modeled recently enacted anti-blight measures after Chula Vista’s. On Wednesday, 8 October, the Escondido City Council also voted to tighten local measures making lenders more accountable for maintenance of empty homes.
| Lenders will respond when it costs them less to maintain the property than to ignore local agency requirements. | ||
Under the Chula Vista ordinance lenders become legally responsible for upkeep as soon as a notice of mortgage default gets filed on a vacant dwelling, before actual ownership of the dwelling returns to the lender. Leeper regards that as “the cutting-edge part of our ordinance”. Chula Vista also requires prompt registration of vacant homes and applies stiff fines as high as US$1000 per day for failure to maintain a property. Since foreclosed properties are subject to frequent resale between mortgage brokers, city officials enforce the fines by sending notices to every name on title documents and placing a lien on the property, which prevents further resale until outstanding fines have been paid. In the year since the ordinance went into effect the city has applied $850,000 in fines and penalties, of which it has collected $200,000 to date. The city has collected an additional $77,000 in registration fees on vacant homes.
Jolie Houston, an attorney in San Jose, believes “Lenders will respond when it costs them less to maintain the property than to ignore local agency requirements.” Traditionally, local governments have resorted to addressing blight problems on abandoned properties with public funds, mowing overgrown lawns and performing other vital functions, then seeking repayment afterward. Chula Vista has moved that responsibility to an upfront obligation upon lenders.
| That kind of measure will add additional costs to banks that have been hit really hard already and ultimately the cost will be transferred down to consumers and investors. | ||
As one of the fastest growing cities in the United States during recent years, Chula Vista saw 22.6% growth between 2000 and 2006, which brought the city’s population from 173,556 in the 2000 census to an estimated 212,756, according to the U.S. Census Bureau. Chula Vista placed among the nation’s 20 fastest growing cities in 2004. A large proportion of local homes were purchased during the recent housing boom using creative financing options that purchasers did not understand were beyond their means. Average home prices in San Diego County declined by 25% in the last year, which is the steepest drop on record. Many homeowners in the region currently owe more than their homes are worth and confront rising balloon payment mortgages that they had expected to afford by refinancing new equity that either vanished or never materialized. In August 2008, Chula Vista’s eastern 91913 zip code had the highest home mortgage default rate in the county with 154 filings and 94 foreclosures, an increase of 154% over one year previously. Regionally, the county saw 1,979 foreclosures in August.
Professionals from the real estate and mortgage industries object to Chula Vista’s response to the crisis for the additional burdens it places on their struggling finances. Said San Diego real estate agent Marc Carpenter, “that kind of measure will add additional costs to banks that have been hit really hard already and ultimately the cost will be transferred down to consumers and investors.” Yet city councils in many communities have been under pressure to do something about increasing numbers of vacant properties. Concentrations of abandoned and neglected homes can attract vandals who hasten the decline of struggling neighborhoods. Jolie Houston explained that city officials “can’t fix the lending problem, but they can try to prevent neighborhoods from becoming blighted.”
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CEO Robert Klein of Safeguard, a property management firm, told the Union Tribune that his industry is having difficulty adapting to the rapidly changing local ordinances. “Every day we discover a new ordinance coming out of somewhere”, he complained. Dustin Hobbs, a spokesman from the California Association of Mortgage Bankers agreed that uneven local ordinances are likely to increase the costs of lending. Hobbs advised that local legislation is unnecessary due to California State Senate Bill 1137, which was recently approved to address blight. Yet according to Houston, the statewide measure falls short because it fails to address upkeep needs during the months between the time when foreclosure begins and when the lender takes title.
byAlma Abell
Prior to embarking on the search to find the best oil and gas construction companies, Edmonton project managers will want to do sufficient research. This may be time consuming in the beginning but ultimately, it will be well worth the effort to find the best oil and gas construction companies Edmonton has to offer. Once you begin to uncover potential candidates, you will want to sit down with them to discuss how they can help you meet your goals.
Years of experience
One of the qualifiers for selecting the best oil and gas companies in Edmonton is to choose them based on their years of experience. A company that has extensive industry experience will be well equipped to handle projects of all sizes and scopes. Whether you are considering an oil and gas company for a temporary or ongoing project, you will want to know that they can support their expertise with years of hands on, industry experience.
Knowledge of the industry
In addition to years of experience, you will also want to choose oil and gas companies Edmonton has available based on their industry knowledge. Having to explain your parameters to a company that doesn’t understand the industry well enough can be very time consuming. Instead, it is better to focus on those candidates who are well equipped to handle your project with skill and expertise.
Extensive inventory of tools
With our extensive inventory of tools, we have the capability to handle any potential project that comes along. With the right tools, a job will go much more smoothly and efficiently. Don’t waste time with companies that always have to rent their tools and never really master how to use them. A professional company will have the tools for the job and will understand how to use them effectively.
By keeping these points in mind, you are sure to find just the right oil and gas construction company for the job.
Visit Platinum Pipefitting, Inc.online at http://platinumpipefitting.com for more information about how we can help you reach your project goals. You can also visit on Facebook.
Friday, December 18, 2020
Last week, on December 8, US-based software company Red Hat announced plans to shift their focus away from CentOS in favour of CentOS stream.
Started in 2004, CentOS has been a free-of-cost free/libre open source software which provided binary-code compatibility with Red Hat Enterprise Linux (RHEL) — Red Hat’s GNU General Public Licensed paid operating system. Gregory Kurtzer told Wikinews he started CAOS Linux around the time when Red Hat announced End of Life for their Red Hat Linux in favour of subscription-based Red Hat Enterprise Linux. CAOS was succeeded by CentOS when Rocky McGaugh, a developer of CAOS rebuilt the source code of RHEL to provide a monetarily free alternative. CentOS was absorbed into Red Hat in 2014, with Red Hat gaining the trademark rights of “CentOS”.
Red Hat also sponsors the development of the Fedora operating system. Until now, software development took place on Fedora, which was later adopted in RHEL, which the Red Hat maintained and provided support for, for those customers who had RHEL subscription. CentOS would then follow RHEL’s release cycle to provide the same features free of cost, but without the support.
Stream was announced in September 2019, just two months after Red Hat was acquired by IBM. CentOS Stream’s development cycle had new features added to it before the features became a part of RHEL. Stream receives more frequent updates, however, it does not follow RHEL’s release cycle.
With CentOS Stream, developments from the community and the Red Hat employees would take place beforehand on both Fedora, and Stream as a rolling release, before those features are absorbed into RHEL. CentOS followed the release cycle of RHEL and therefore it was a stable distribution. Features available in CentOS were tried and tested by Fedora, and then RHEL maintainers.
Red Hat’s Chief Technical Officer Chris Wright wrote in the announcement “CentOS Stream isn’t a replacement for CentOS Linux; rather, it’s a natural, inevitable next step intended to fulfill the project’s goal of furthering enterprise Linux innovation.” Since the announcement was made, many people expressed their anger on Internet Relay Chat (IRC), Reddit and CentOS project’s mailing list. CentOS 8’s End of Life (EOL) has been moved up from May 2029 to December 31, 2021, while CentOS 7 is expected to receive maintenance updates through June 2024, outliving CentOS 8.
Soon after Red Hat’s announcement, Kurtzer announced his intentions to develop Rocky Linux, to fill the role CentOS had been playing for so long. Kurtzer said Rocky Linux was named after Rocky McGaugh. “Thinking back to early CentOS days… My cofounder was Rocky McGaugh. He is no longer with us, so as a H/T [hat tip] to him, who never got to see the success that CentOS came to be, I introduce to you…Rocky Linux”, Kurtzer wrote. Wikinews discussed with Kurtzer the beginning of CentOS, and future of Rocky Linux.
While no formal date of release has been announced for Rocky Linux, Kurtzer said they are planning to release the CentOS replacement before the end of life of CentOS 8. Kurtzer also said Rocky Linux will run on both x86-64 and ARM-based processors, and CentOS users would be able to convert their OS to Rocky Linux just by running a single command.
Saying Rocky Linux is for the community, Kurtzer said he “take[s] the responsibility of ensuring that all decisions are in favor of the community and the project and free from corporate control” including his own company. Talking about the attention from the userbase Rocky Linux has received, Kurtzer said, “I have never seen an open community come together this fast and be this passionate about working together towards a common goal.”
Saturday, June 3, 2006
Human-to-human transmission of the H5N1 Avian Flu (Bird Flu) virus was earlier suspected in an Indonesian nurse currently hospitalised who was showing symptoms of the virus. However it is now being reported that tests on the woman for avian virus have been returned showing negative results, and that the samples are being sent to a World Health Organization approved laboratory in Hong Kong for further analysis and confirmation.
“Thank God, the result came back negative,” said senior official for the Indonesian Health Ministry, Hariadi Wibisono.
The nurse had been in close contact with two children, brother and sister, who have died. The sister, nine, was confirmed of having died from the virus by local lab tests. The brother was buried before any blood tests could be taken, but showed similar symptoms.
It was reported on Friday that an analysis has shown that the virus has not mutated, and the WHO has said that there was no evidence so far of human-to-human transmission.
Other members of the same family are currently ill, but all members have received the Tamiflu antiviral drug.
“I think it is a cluster. The local test from the victim in Pamulang is bird flu positive. The symptoms of the virus are very similar to previous clusters we’ve had. The parents are also suffering from flu, and we are giving them a full dose of Tamiflu now,” said Indonesia’s Health Minister, Siti Fadilah Supari.
“The characteristics of germ (the boy had) is very similar (to his sister’s), and now their mother and father are suffering from flu. They are all in the Pamulang district,” added Supari.
The nurse, whose initials are “C.I.,” 25, has been put in isolation at Bandung’s Hasan Sadikin Hospital, but officials say that her condition is stable and that her case may be the result of human-to-human transmission due to the fact that she has not had any contact with poultry.
“We could not confirm whether she is positive of having been infected by avian influenza virus or not, although she had earlier have contacts with siblings, 18-year old Ad and 10-year old Ai, who died of bird flu virus recently,” said Hadi Yusuf, chief of the Bird Flu team at Sadikin Hospital.
“When she arrived at this hospital last night, her body temperature was very high, namely 39.6 Celsius degrees but now it has decreased to 37 Celsius degrees. After considering her contact with dead bird flu victims, we declared her a suspected bird flu case. But she is still fully conscious, her breathing problems are not too serious and she’s not experiencing chest pain,” added Yusuf.
The names of the children and the nurse have not been released. The nurse is undergoing treatment and has been administered Tamiflu. She is expected to be released when the required amount of doses is given, which officials say could be as early as next week.
Thursday, June 23, 2011
NASA’s Cassini–Huygens spacecraft has discovered evidence for a large-scale saltwater reservoir beneath the icy crust of Saturn’s moon Enceladus. The data came from the spacecraft’s direct analysis of salt-rich ice grains close to the jets ejected from the moon. The study has been published in this week’s edition of the journal Nature.
Data from Cassini’s cosmic dust analyzer show the grains expelled from fissures, known as tiger stripes, are relatively small and usually low in salt far away from the moon. Closer to the moon’s surface, Cassini found that relatively large grains rich with sodium and potassium dominate the plumes. The salt-rich particles have an “ocean-like” composition and indicate that most, if not all, of the expelled ice and water vapor comes from the evaporation of liquid salt-water. When water freezes, the salt is squeezed out, leaving pure water ice behind.
Cassini’s ultraviolet imaging spectrograph also recently obtained complementary results that support the presence of a subsurface ocean. A team of Cassini researchers led by Candice Hansen of the Planetary Science Institute in Tucson, Arizona, measured gas shooting out of distinct jets originating in the moon’s south polar region at five to eight times the speed of sound, several times faster than previously measured. These observations of distinct jets, from a 2010 flyby, are consistent with results showing a difference in composition of ice grains close to the moon’s surface and those that made it out to the E ring, the outermost ring that gets its material primarily from Enceladean jets. If the plumes emanated from ice, they should have very little salt in them.
“There currently is no plausible way to produce a steady outflow of salt-rich grains from solid ice across all the tiger stripes other than salt water under Enceladus’s icy surface,” said Frank Postberg, a Cassini team scientist at the University of Heidelberg in Germany.
The data suggests a layer of water between the moon’s rocky core and its icy mantle, possibly as deep as about 50 miles (80 kilometers) beneath the surface. As this water washes against the rocks, it dissolves salt compounds and rises through fractures in the overlying ice to form reserves nearer the surface. If the outermost layer cracks open, the decrease in pressure from these reserves to space causes a plume to shoot out. Roughly 400 pounds (200 kilograms) of water vapor is lost every second in the plumes, with smaller amounts being lost as ice grains. The team calculates the water reserves must have large evaporating surfaces, or they would freeze easily and stop the plumes.
“We imagine that between the ice and the ice core there is an ocean of depth and this is somehow connected to the surface reservoir,” added Postberg.
The Cassini mission discovered Enceladus’ water-vapor and ice jets in 2005. In 2009, scientists working with the cosmic dust analyzer examined some sodium salts found in ice grains of Saturn’s E ring but the link to subsurface salt water was not definitive. The new paper analyzes three Enceladus flybys in 2008 and 2009 with the same instrument, focusing on the composition of freshly ejected plume grains. In 2008, Cassini discovered a high “density of volatile gases, water vapor, carbon dioxide and carbon monoxide, as well as organic materials, some 20 times denser than expected” in geysers erupting from the moon. The icy particles hit the detector target at speeds between 15,000 and 39,000 MPH (23,000 and 63,000 KPH), vaporizing instantly. Electrical fields inside the cosmic dust analyzer separated the various constituents of the impact cloud.
“Enceladus has got warmth, water and organic chemicals, some of the essential building blocks needed for life,” said Dennis Matson in 2008, Cassini project scientist at NASA’s Jet Propulsion Laboratory in Pasadena, California.
“This finding is a crucial new piece of evidence showing that environmental conditions favorable to the emergence of life can be sustained on icy bodies orbiting gas giant planets,” said Nicolas Altobelli, the European Space Agency’s project scientist for Cassini.
“If there is water in such an unexpected place, it leaves possibility for the rest of the universe,” said Postberg.
byalex
It is important to find a lawn service company which provides a variety of garden care services to ensure your garden looks fresh and green all throughout years. Maintaining a yard sometimes goes beyond our capabilities. So, if you want to have a green and aerated garden, you have to seek professional assistance from a lawn service company. There are numerous garden care companies which offer a huge range of lawn maintenance services.
Before you contact a lawn service company in your region, you should prepare a list of a few yard care services which you need for your garden. There are companies which provide various lawn care services in packages to give you complete garden care services. Now let us discuss about a few popular services provided by a lawn service company.
To know more about companies providing lawn service, Needham, MA, residents should browse the Internet and find information about some leading garden care companies in their region. They can also get necessary information about such yard maintenance firms from their peers and neighbors who took professional assistance of a garden care company in the recent past.